**Job Description**
Humanitas University is seeking a Post-Doctoral Research Fellow to support research within the Experimental Neuropathology Unit. The project, “Dissecting microglia vulnerability to stress response in Multiple Sclerosis through human iPSC modelling,” aims to investigate molecular mechanisms underlying microglial vulnerability to cellular senescence in Multiple Sclerosis (MS) using human iPSC-derived models and advanced gene editing. The research integrates hiPSC-derived microglia models, genome-wide CRISPR-Cas9 screenings, single-cell CRISPR-seq and multi-omics, and organoid-based brain aging models to identify therapeutic targets for halting MS progression by rejuvenating microglial function.
**Skills & Abilities**
• Proven experience in hiPSC culture and differentiation
• Proven experience in CRISPR/Cas9 gene editing
• Fluent written and spoken English
• Strong scientific and professional track record
• Experience with brain organoid models (Preferred)
• Familiarity with single-cell sequencing and multi-omics data (Preferred)
• Ability to work independently and collaboratively in a multidisciplinary team
**Qualifications**
Required Degree(s) in:
• Biology
• Biotechnology
• Molecular Biology
• Biomedical Sciences
• Related fields
**Experience**
Other:
• Proven experience in hiPSC culture and differentiation
• Proven experience in CRISPR/Cas9 gene editing
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