PhD position in Translational Chemical Immunology

**Job Description**
The Department of Chemical Biology and Immunology (CBI) is seeking a Ph.D. candidate to investigate autoantigen-specific cell therapies utilizing synthetic chimeric autoantigen-receptors (sCAARs). This project, funded by ZonMW Open Competition, aims to advance cellular therapies towards precise cellular immunotherapy by developing synthetic ligands targeting autoreactive B cells specific to autoantigens that cannot be cellularly expressed as CAARs. It is a highly multidisciplinary collaboration between synthetic chemists and immunologists from Leiden University Medical Centre, and computational scientists from TU Delft, focusing on the development of the next generation of synthetic CAAR cell therapy for serious autoimmune conditions. The candidate will receive training at both the CBI department of Leiden University and the Leiden University Medical Centre.

**Skills & Abilities**
• Independent in performing synthetic organic chemistry
• High intrinsic motivation for multidisciplinary and translational research
• Good communication skills

**Qualifications**
Required Degree(s) in:
• Chemical Biology
• Chemistry
• Related discipline combining chemistry and biology (Master of Science or equivalent)

**Experience**
Other:
• Experience with (immune) cells, microscopy imaging methods, and/or cell-based assays is highly preferred

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